Creation and the philosophy of science: Freedom, contingence and the modality of the natural sciences

Understanding creation through the theological loci of Christology and Trinitarian theology gives a view of the natural world as both contingent and free. This distinctively Christian view of the natural world carries implications for the natural sciences in terms of philosophical modality. This paper explores three such themes: (i) the nature of reason; (ii) the character of theories; and (iii) the relationship between discursivity and the logic of reality

Sex differences in variability across timescales in BALB/c mice.

BackgroundFemales are markedly underinvestigated in the biological and behavioral sciences due to the presumption that cyclic hormonal changes across the ovulatory cycle introduce excess variability to measures of interest in comparison to males. However, recent analyses indicate that male and female mice and rats exhibit comparable variability across numerous physiological and behavioral measures, even when the stage of the estrous cycle is not considered. Hormonal changes across the ovulatory cycle likely contribute cyclic, intra-individual variability in females, but the source(s) of male variability has, to our knowledge, not been investigated. It is unclear whether male variability, like that of females, is temporally structured and, therefore, quantifiable and predictable. Finally, whether males and females exhibit variability on similar time scales has not been explored.MethodsThese questions were addressed by collecting chronic, high temporal resolution locomotor activity (LA) and core body temperature (CBT) data from male and female BALB/c mice.ResultsContrary to expectation, males are more variable than females over the course of the day (diel variability) and exhibit higher intra-individual daily range than females in both LA and CBT. Between mice of a given sex, variability is comparable for LA but the inter-individual daily range in CBT is greater for males. To identify potential rhythmic processes contributing to these sex differences, we employed wavelet transformations across a range of periodicities (1-39 h).ConclusionsAlthough variability in circadian power is comparable between the sexes for both LA and CBT, infradian variability is greater in females and ultradian variability is greater in males. Thus, exclusion of female mice from studies because of estrous cycle variability may increase variance in investigations where only male measures are collected over a span of several hours and limit generalization of findings from males to females

Identification of a lineage of multipotent hematopoietic progenitors

All multipotent hematopoietic progenitors in C57BL-Thy-1.1 bone marrow are divided among three subpopulations of Thy-1.1^(lo) Sca-1^+ Lin^(-/lo) c-kit^+ cells: long-term reconstituting Mac-1^-CD4^-c-kit^+ cells and transiently reconstituting Mac-1^(lo)CD4^-or Mac-1^(lo) CD4^(lo) cells. This study shows that the same populations, with similar functional activities, exist in mice whose hematopoietic systems were reconstituted by hematopoietic stem cells after lethal irradiation. We demonstrate that these populations form a lineage of multipotent progenitors from long-term self-renewing stem cells to the most mature multipotent progenitor population. In reconstituted mice, Mac-1- CD4^-c-kit^+ cells gave rise to Mac-1^(lo)CD4^- cells, which gave rise to Mac-1^(lo)CD4^(lo) cells. Mac-1^- CD4^-c-kit^+ cells had long-term self-renewal potential, with each cell being capable of giving rise to more than 10^4 functionally similar Mac-1^-CD4^-c-kit^+ cells. At least half of Mac-1^(lo)CD4^- cells had transient self-renewal potential, detected in the spleen 7 days after reconstitution. Mac-1^(lo)CD4^(lo) cells did not have detectable self-renewal potential. The identification of a lineage of multipotent progenitors provides an important tool for identifying genes that regulate self-renewal and lineage commitment

Preliminary Results on Chemical Thinning of Apple Blossoms with Ammonium Thiosulphate, NAA, and Ethephon

Preliminary tests were carried out using ammonium thiosulphate as a chemical thinning agent for apple ('Cox's Orange Pippin' and 'Braeburn') blossoms. Ethephon and NAA (1-napthylacetic acid) were included for comparison. Whole tree sprays of 37g/l ammonium thiosulphate over-thinned 'Cox's Orange Pippin' blossoms and severely scorched blossoms, foliage, and apical meristems. Ethephon at 0.35 g/l also over-thinned, and NAA thinned to an intermediate extent when compared with the controls. When the lower concentration of 3.7 g/l ammonium thiosulphate was directly applied to stamens and styles of 'Braeburn' blossoms by brush, initial fruit set was only 30% that of untreated blossoms. When 0.35 g/I ethephon was directly applied by brush to spur leaves or petals of 'Braeburn' blossoms at pink bud, initial fruit set was only 23% that of untreated blossoms. lt is concluded that ammonium thiosulphate has the potential to thin apple blossoms. Further experiments to define optimum concentrations and spray volumes are needed

Streaming potential modeling in fractured rock: Insights into the identification of hydraulically active fractures

Numerous field experiments suggest that the self-potential (SP) geophysical method may allow for the detection of hydraulically active fractures and provide information about fracture properties. However, a lack of suitable numerical tools for modeling streaming potentials in fractured media prevents quantitative interpretation and limits our understanding of how the SP method can be used in this regard. To address this issue, we present a highly efficient two-dimensional discrete-dual-porosity approach for solving the fluid flow and associated self-potential problems in fractured rock. Our approach is specifically designed for complex fracture networks that cannot be investigated using standard numerical methods. We then simulate SP signals associated with pumping conditions for a number of examples to show that (i) accounting for matrix fluid flow is essential for accurate SP modeling and (ii) the sensitivity of SP to hydraulically active fractures is intimately linked with fracture-matrix fluid interactions. This implies that fractures associated with strong SP amplitudes are likely to be hydraulically conductive, attracting fluid flow from the surrounding matrix.Comment: 8 pages, 2 figure

Key Issues Generated from the XI International Rangeland Congress 2021: Summary and Way Forward

The important issues, knowledge gaps, and evolving research approaches for the global rangelands are summarised in this review of submissions to the Joint XXIV International Grasslands and XI International Rangelands Congress (IGC/IRC). In the big picture, it is concluded that stand-alone studies of livestock production are becoming rare compared to that of the past International Rangelands Congresses (IRC). Rather, added effort is now being directed at understanding the fuller context of social-ecological systems (SESs) on rangelands in a quest to improve the prospects for sustainable resource management as well as the enhancement of human welfare. Although climate change is upon us, there was still a dearth of papers that dealt with broad- scaled climate-adaptation per se; opportunities to improve local drought response were the default topics here with a focus on implementing better drought early warning systems and integrating perspectives among producers and scientists. Invasive species challenges remain as prominent global concerns, and woody encroachment is viewed as a major contributor to rangeland degradation. Treatments to combat rangeland degradation can involve innovative layering methods incorporating grazing management and use of prescribed fire. While there is an important backdrop concerning ecosystem services from rangelands, research in this area is still in its infancy. Analysing trade-offs between production and conservation for services such as carbon sequestration loom large going forward. There were relatively few papers concerning wildlife, tourism, and associated issues; successes and challenges for natural resource conservancies were noted, in particular. These are topics that merit more creative research and development attention in the future. Some contributions highlighted the important issue of landscape conversion from rangelands to cultivation; in conjunction with human population growth, loss of such key resources can be very negative for wildlife and associated values. In terms of pastoralism and related sub-themes, while it was noted that the majority of studies now embrace SESs and integrated, participatory, action- oriented approaches, there is little effort to standardize methodologies. A focus on repeatable methods can help grow sustainability science on rangelands, and this is a challenge for research and outreach education. The volume of studies submitted overall indicated a decided numerical advantage for the Global South over the Global North. Why this is the case remains unclear, however. Disciplinary research traditions in wealthier nations may not yet provide the incentives needed to spur innovative SES work. Finally, policy makers are seen by many investigators as being ignorant of rangeland development issues. It is argued, however, that this view has not changed for 40 years. How to better engage policy makers in comprehensive SES projects is an important future goal. Policy makers themselves can then also become human research subjects in the overall process. Based on our review the future for IRC stakeholders is clear: Continue the expansion of interdisciplinary SES and action-based approaches and increase attention to climate-change adaptation/mitigation, ecosystem services, community-based development, human empowerment, market development, poverty mitigation, and creation of effective policy frameworks